Not known; not sympathomimetic; could raise dopamine ranges in the Mind by binding into the dopamine transporter and inhibiting dopamine reuptake
Advarsler og forsiktighetsregler Snakk med lege eller apotek fileør du bruker Modiodal dersom du Har hjerteproblemer eller høyt blodtrykk. Legen din må sjekke dette regelmessig mens du tar Modiodal.
Andre ting du bør snakke med lege eller apotek om Noen personer har rapportert at de har hatt selvmordstanker, intense tanker eller atferd mens de har tatt dette legemidlet. Ta umiddelbart kontakt med lege dersom du merker at du blir deprimert, føler deg aggressiv eller fiendtlig ovenfor andre mennesker eller får selvmordstanker eller andre endringer ved din atferd (se avsnitt 4).
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Use modafinil for the duration of pregnancy with warning if Advantages outweigh pitfalls. Animal scientific tests show threat and human reports are usually not accessible, or neither animal nor human scientific studies ended up performed.
It does NOT involve all details about the probable makes use of, Instructions, warnings, precautions, interactions, adverse outcomes, or risks which could utilize to modafinil. This info isn't precise clinical assistance and won't change data you get in the healthcare company. You must talk to the Health care service provider for complete details about the pitfalls and great things about using this medicine.
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Stiripentol is actually a CYP3A4 inhibitor and inducer. Keep an eye on CYP3A4 substrates coadministered with stiripentol for enhanced or reduced outcomes. CYP3A4 substrates may possibly call for dosage adjustment.
etravirine will lessen the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
tecovirimat will enhance the level or outcome of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Check. Tecovirimat is actually a weak inhibitor of CYP2C8 and CYP2C19. Keep track of for adverse effects if coadministered with delicate substrates of those enzymes.
B: Could possibly be appropriate. Both animal scientific studies demonstrate no threat but human research not available or animal scientific tests showed insignificant pitfalls and human research finished and showed no risk.
Warfarin's much less strong R-enantiomer is metabolized partly by CYP3A4 (and also CYP1A2 and CYP2C19). Watch INR much more click here routinely if coadministered with inhibitors of these isoenzymes and regulate warfarin dose if needed.
Modafinil is often taken Each and every morning to circumvent daytime sleepiness, or 1 hour before the get started of a piece shift to take care of get the job done-time rest disorders.
Minor (one)modafinil will raise the level or outcome of rabeprazole by impacting hepatic enzyme CYP2C19 metabolism. Small/Importance Unfamiliar. Net impact on pantoprazole steps mysterious as a result of opposing effects of CYP450 enzymes; observe